Propranolol in schizophrenia. Clinical, metabolic, and pharmacological findings.
Arch Gen Psychiatry
; 37(6): 685-90, 1980 Jun.
Article
em En
| MEDLINE
| ID: mdl-7387339
ABSTRACT
Six schizophrenic patients received propranolol hydrochloride to evaluate pharmacological, endocrinological, and antipsychotic properties of the drug. They had previously been unsuccessfully treated with phenothiazines. After a drug-free period of two weeks, propranolol was administered in gradually increasing doses. After two to four weeks, a low dose of phenothiazines was added. The clinical effect was evaluated using the Comprehensive Psychopathological Rating Scale. Three of the six patients showed a definite improvement with propranolol therapy given as a sole treatment. Propranolol in plasma was positively correlated to dosage. The proportion of its major metabolite, 4-hydroxy-propranolol, decreased with increasing drug dose. Melatonin and prolactin levels in serum decreased noticeably with propranolol treatment. When phenothiazines were added, prolactin increased above drug-free levels. These results support the view that propranolol has an antipsychotic potential that needs further evaluation in clinical trials.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propranolol
/
Esquizofrenia
/
Psicologia do Esquizofrênico
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Arch Gen Psychiatry
Ano de publicação:
1980
Tipo de documento:
Article