C-Glucuronidation of the acetylenic moiety of ethchlorvynol in the rabbit.

Abolin, C R; Tozer, T N; Craig, J C; Gruenke, L D

Abolin, C R; Tozer, T N; Craig, J C; Gruenke, L D.

Science ; 209(4457): 703-4, 1980 Aug 08.

Article em En | MEDLINE | ID: mdl-7394528

ABSTRACT

ABSTRACT

An acetylenic C-glucuronide of the sedative-hypnotic drug ethchlorvynol was isolated from rabbit urine as the major metabolite. The C-glucuronide represents a novel metabolic pathway for acetylenes and is a rare example of the formation of a carbon-glucuronide bond in mammalian systems.

Assuntos

Etclorvinol/análogos & derivados; Etclorvinol/metabolismo; Acetileno; Animais; Radioisótopos de Carbono; Etclorvinol/urina; Glucuronidase; Espectroscopia de Ressonância Magnética; Espectrometria de Massas; Coelhos; Espectrofotometria Infravermelho

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Etclorvinol Limite: Animals Idioma: En Revista: Science Ano de publicação: 1980 Tipo de documento: Article

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