The effects of hemorrhage and sodium depletion on plasma concentrations of angiotensin II and [des-Asp1]angiotensin II in the rat.

ABSTRACT

Plasma concentrations of angiotensin II (PAII) and [des-Asp1]angiotensin II (Pdes-Asp1-AII) were measured before and after hemorrhage and acute and chronic depletion of sodium. Graded hemorrhage increased PAII from 30 +/- 5 to 220 +/- 41 and 989 (526-1290) pmol/liter and Pdes-Asp1-AII from 47 +/- 11 to 216 +/- 72 and 532 +/- 178 pmol/liter. Furosemide increased PAII from 26 +/- 4 to 178 +/- 37 but did not change Pdes-Asp1-AII (31 +/- 3 to 31 +/- 4 pmol/liter). Deprivatin of dietary sodium increased PAII from 25+/- 6 to 136+/- 22 pmol/liter and Pdes-Asp1-AII from 41 +/- 4 to 71 +/- 15 pmol/liter. The ratio of PAII to Pdes-Asp1-AII was increased by all three stimuli (P < 0.05 to P < 0.001). Pdes-Asp1-AII II is unlikely to mediate the effects of hemorrhage and changes in sodium balance on aldosterone secretion in the rat.