Molecular basis of reovirus virulence. Role of the M2 gene.
J Exp Med
; 152(4): 853-68, 1980 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-7420022
ABSTRACT
The mammalian reoviruses (serotype 1, strain Lang and serotype 3, strain Dearing) differ in their sensitivity to digestion by chymotrypsin. We have found that the M2 double-stranded RNA (dsRNA) genome segment (encoding the micro1C outer capsid polypeptide) is responsible for this property. In addition to determining response to protease treatement in vitro, we have found that the M2 genome segment also determines the ability of these two viruses successfully to initiate local and systemic infection in newborn mice after peroral inoculation. Thus the M2 dsRNA segment defines a new virulence gene of the mammalian reoviruses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reoviridae
/
RNA Viral
/
Genes Virais
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1980
Tipo de documento:
Article