Supplemental dietary carnitine and lipid metabolism in exercising rats.

ABSTRACT

Rats were physically trained by treadmill running and fed normal, high fat, or identical diets supplemented with 1.0% D,L-carnitine. Fatty acid oxidation, stimulated by exercise and/or by a high fat diet was studied to determine if it might be further augmented by supplemental dietary carnitine. Fatty acid oxidation in vitro or in vivo was unaffected by carnitine feeding. Carnitine feeding was associated with an increase in heart and muscle palmitylcarnitine acyltransferase activity and reduced serum cholesterol in trained rats fed the high fat diet. Under the conditions of this study, supplemental dietary carnitine did not greatly alter glyceride synthesis, lipolysis, or fatty acid oxidation, which indirectly indicates that the increased demands for fatty acid oxidation resulting from exercise or from fat feeding are adequately supported by endogenous levels of carnitine.