HPV replication in experimental models: effects of interferon.
Antiviral Res
; 24(2-3): 175-90, 1994 Jul.
Article
em En
| MEDLINE
| ID: mdl-7526790
ABSTRACT
Preclinical evaluation of the effectiveness of interferon (IFN) therapy on human papillomaviruses (HPV) has been hampered by the inability to propagate these viruses in cell culture. Nonetheless, interferon is used extensively in the treatment of HPV infections. Alpha interferons in particular have found a place in the treatment of anogenital disease, plantar warts, and laryngeal papillomas. While their is significant clinical evidence to suggest that interferon is useful in therapy of disease, the cellular mechanism(s) (i.e., antiviral, antiproliferative, immunomodulatory) by which IFN is able to control HPV-induced pathology is not well understood. This review focuses on experimental animal and cell culture models which are currently being used to help identify the antiviral, antiproliferative and immunomodulatory effects of IFN on HPV infection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
Interferons
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Antiviral Res
Ano de publicação:
1994
Tipo de documento:
Article