Effects of unilateral lesion of the nucleus basalis magnocellularis on carbachol- and serotonin-stimulated [3H]inositolmonophosphate accumulation in rat fronto-parietal cortex.
Neurosci Lett
; 193(1): 68-70, 1995 Jun 23.
Article
em En
| MEDLINE
| ID: mdl-7566670
ABSTRACT
We examined the effects of ibotenic acid induced unilateral lesion of the nucleus basalis magnocellularis (nBM) on carbachol- and serotonin-stimulated phosphoinositide (PI) breakdown in miniprisms obtained from rat fronto-parietal cortex 1 week following the lesion. Lesion-side muscarinic and serotoninergic receptor responsivity to agonist increased linearly relative to the severity of the nBM lesion as measured by choline acetyltransferase (ChAT) activity. These results provide further evidence for an interaction between central cholinergic and serotoninergic neurons.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Substância Inominada
/
Carbacol
/
Serotonina
/
Ácido Ibotênico
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos