The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q.
Biochim Biophys Acta
; 1262(2-3): 105-12, 1995 Jun 09.
Article
em En
| MEDLINE
| ID: mdl-7599184
ABSTRACT
Brain factor-1 (BF-1) is a member of the fork head gene family which shows expression restricted to the neurons of the developing telencephalon in rodents and man. We have isolated a second human gene (HBF-2), which is also strongly expressed in embryonic brain and has very high homology to both the rat and human brain factor-1 genes and the retroviral oncogene qin. The HBF-2 cDNA was isolated from a human fetal brain expression library and contains a putative open reading frame of 479 amino acids. The HBF-2 gene is strongly expressed in fetal brain and also with lower levels of expression in several adult tissues. At the genomic level the gene for HBF-1 contains an 500 bp intron situated between the DNA binding domain II and the fork head domain while that of HBF-2 is intronless. The two genes are clustered on human chromosome 14q11-13.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Telencéfalo
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Cromossomos Humanos Par 14
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Proteínas de Ligação a DNA
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Proteínas do Tecido Nervoso
Limite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Alemanha