Study on cathepsin B activity in human thyroid tumors.
Auris Nasus Larynx
; 22(1): 43-8, 1995.
Article
em En
| MEDLINE
| ID: mdl-7677635
ABSTRACT
Cathepsin B activity was measured in human thyroid tissue obtained surgically from 2 patients with Grave's disease, 3 with follicular adenoma, 4 with papillary carcinoma, and 4 with follicular carcinoma. Three normal thyroid tissues were also studied. Comparisons were made between cathepsin B activity and clinical findings, including histopathological diagnosis and the presence or absence of extra-capsular invasion and metastasis. The abilities of original tumors to degrade type I and type IV collagen were also measured. Mean cathepsin B activities of both specimens with benign and those with malignant disease were significantly higher than those of normal thyroid. On cases of thyroid carcinoma, those with extra-capsular invasions and metastasis had the highest cathepsin B activities. Cases with high cathepsin B activities also tended to show high type I and IV collagen degrading abilities. These findings suggest that cathepsin B plays a role in the development of extra-capsular invasion and lymph node metastasis in human thyroid tumors.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Glândula Tireoide
/
Catepsina B
/
Biomarcadores Tumorais
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Auris Nasus Larynx
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Japão