Expression of CD59, a regulator of the membrane attack complex of complement, on human astrocytes.
Brain Res Mol Brain Res
; 18(4): 335-8, 1993 Jun.
Article
em En
| MEDLINE
| ID: mdl-7686996
ABSTRACT
The present study demonstrates that human astrocytes synthesize and express CD59, a regulator of the membrane attack complex of complement. This was shown by flow cytometry following staining of astrocytes with MAb to CD59, and Western blotting of astrocyte lysates, which revealed the characteristic 18-23,000 M(r) band of CD59. Synthesis of CD59 by astrocytes was confirmed by detection of CD59 specific mRNA by polymerase chain reaction. A low level of C3 deposition occurred on astrocytes following exposure to autologous serum. CD59 may prevent subsequent damage from C5b-9 and protect astrocytes during inflammatory and infectious disorders of the nervous system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Antígenos CD
/
Complexo de Ataque à Membrana do Sistema Complemento
/
Astrócitos
Limite:
Humans
Idioma:
En
Revista:
Brain Res Mol Brain Res
Assunto da revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Austrália