Effect of dose and specific activity on tissue distribution of indium-111-pentetreotide in rats.
J Nucl Med
; 36(4): 623-7, 1995 Apr.
Article
em En
| MEDLINE
| ID: mdl-7699456
ABSTRACT
UNLABELLED To increase the target-to-background ratio in receptor scintigraphy, we hypothesized that receptor scintigraphy is best performed using the lowest possible mass with the highest possible specific radioactivity of the radioligand. METHODS:
Rats were injected with 2 or 10 micrograms of unlabeled octreotide or 2 or 10 micrograms of 111In-pentetreotide. Scintigraphic images were then obtained from 10 min before to 20 min after the 111In injection.RESULTS:
In some instances, there was a significant increase in 111In uptake in somatostatin receptor-positive organs. In others, there was a significant decrease. Since no significant differences were found in background radioactivity in the percent dose uptake of 111In in receptor-negative organs, these data indicate that target-to-background ratios can be increased by the administration of nonradiolabeled peptides under select conditions.CONCLUSION:
The uptake of 111In-pentetreotide in somatostatin receptor-positive organs results in a tissue-specific bell-shaped function of the injected mass of the radiopharmaceutical. This curve may also apply to somatostatin receptor-positive tumors, the visualization of which may be enhanced by optimizing the mass of 111In-pentetreotide.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Somatostatina
/
Radioisótopos de Índio
Limite:
Animals
Idioma:
En
Revista:
J Nucl Med
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Holanda