Trypanosoma cruzi: immunological cross-reactivity of the major cysteinyl proteinase (cruzipain) with a parasite cytosol acidic antigen (FIV).
Acta Trop
; 58(3-4): 337-43, 1994 Dec.
Article
em En
| MEDLINE
| ID: mdl-7709872
ABSTRACT
This paper shows that a polyclonal monospecific rabbit antiserum to cruzipain, the major T. cruzi cystein proteinase, cross-reacts with a cytosol acidic antigen (F IV) isolated from the epimastigote stage of the same parasite. In addition, antibodies specific for F IV purified from chagasic patient sera or murine anti F IV sera, also react with cruzipain. This was demonstrated by ELISA, DOT-ELISA, native and electrophoretic Immunoblot. These findings suggest that F IV contains an antigen immunologically cross-reactive with cruzipain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trypanosoma cruzi
/
Anticorpos Antiprotozoários
/
Cisteína Endopeptidases
/
Doença de Chagas
/
Antígenos de Protozoários
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Trop
Ano de publicação:
1994
Tipo de documento:
Article