Quantification of the serotonin hyperinnervation in adult rat neostriatum after neonatal 6-hydroxydopamine lesion of nigral dopamine neurons.
Brain Res
; 669(2): 303-8, 1995 Jan 16.
Article
em En
| MEDLINE
| ID: mdl-7712186
ABSTRACT
Light microscope autoradiography after uptake and storage of tritiated serotonin (5-HT) in brain slices was used to count 5-HT axon terminals (varicosities) in the 5-HT-hyperinnervated neostriatum of adult rats subjected to neonatal 6-hydroxydopamine treatment and age-matched, normal controls. After correction for incomplete autoradiographic exposure and for section thickness, the results were expressed in millions of varicosities per mm3 of tissue. Control values ranged from 4.8 in the rostral to 6.3 in the caudal neostriatum (5.8 at intermediate level), for an average of 5.6. The corresponding values in 5-HT-hyperinnervated tissue ranged from 9.7 to 7.7 (8.8 at intermediate level), for an average of 8.7 and increases of 102%, 52% and 22% above control in the rostral, intermediate and caudal neostriatum, respectively (average increase of 55%). These data confirmed the predilection of the 5-HT hyperinnervation for the rostral neostriatum and demonstrated its presence in the caudal neostriatum also.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Serotonina
/
Oxidopamina
/
Neostriado
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Canadá