Maturation status of small intestine epithelium in rats deprived of dietary nucleotides.
Life Sci
; 56(19): 1623-30, 1995.
Article
em En
| MEDLINE
| ID: mdl-7723591
ABSTRACT
We describe the changes of several brush-border enzymatic activities in different subpopulations of epithelial cells, separated sequentially from the villus tip-to-crypt axis of the small intestine, induced by deprivation of dietary nucleotides for different periods of time in adult rats. Deprivation of dietary nucleotides lead to a decrease in the content and specific activity of alkaline phosphatase, leucine-aminopeptidase, maltase, sucrase and lactase in the villus tip, but had little effect on the crypt zone. The effect of the nucleotide deprivation on the enzymatic activity progressively increased towards the tip of the villus. Since these enzymes are maturation markers of the intestinal cells, these results support the idea that dietary nucleotides affect the maturation status of small-intestine epithelium.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Intestino Delgado
/
Nucleotídeos
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Espanha