Structural similarity between binding sites in influenza sialidase and isocitrate dehydrogenase: implications for an alternative approach to rational drug design.
Protein Sci
; 3(7): 1128-30, 1994 Jul.
Article
em En
| MEDLINE
| ID: mdl-7920262
ABSTRACT
Using searching techniques based on algorithms derived from graph theory, we have established a similarity between a 3-dimensional cluster of side chains implicated in drug binding in influenza sialidase and side chains involved in isocitrate binding in Escherichia coli isocitrate dehydrogenase. The possible implications of the use of such comparative methods in drug design are discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orthomyxoviridae
/
Desenho de Fármacos
/
Isocitrato Desidrogenase
/
Neuraminidase
Idioma:
En
Revista:
Protein Sci
Assunto da revista:
BIOQUIMICA
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Reino Unido