Bacteriophages as tools for vaccine development.
Dev Biol Stand
; 82: 43-7, 1994.
Article
em En
| MEDLINE
| ID: mdl-7958482
ABSTRACT
The construction of live recombinant bacterial vaccines requires a reasonably sophisticated genetic system for the introduction, stabilization and expression of foreign antigen genes. Bacteriophages offer a rich collection of tools that can be used for vaccine construction, including site-specific integration-proficient vectors, non-antibiotic selectable markers and signals for efficient transcription and translation of foreign genes. We describe the characterization of a temperate phage of the mycobacteria, mycobacteriophage L5, and application of these phage studies for the construction of recombinant BCG vaccines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bacteriófagos
/
Vacina BCG
/
Vacinas Sintéticas
/
Vetores Genéticos
Idioma:
En
Revista:
Dev Biol Stand
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Panamá