An equine B cell surface antigen defined by a monoclonal antibody.
Vet Immunol Immunopathol
; 42(1): 91-102, 1994 Jul.
Article
em En
| MEDLINE
| ID: mdl-7975183
ABSTRACT
A surface antigen of equine B lymphocytes was identified using the Equine Leucocyte Antigen Workshop antibody WS 65. This marker was expressed on almost all equine B cells, but not on T cells, granulocytes or thymocytes. WS 65 strongly stained cells in the follicular areas of lymph nodes and cells in the splenic nodules when tested on frozen tissue sections by immunohistochemistry. Equine leukemic T cells were not labeled by WS 65, and neither were the cells from a horse with B cell leukemia, although these latter cells carried surface immunoglobulin. Immunoprecipitation of lymphocyte membrane molecules with the antibody produced a band at 85-90 kDa under reducing conditions. The equine B cell antigen defined by WS 65 appears to be different from surface immunoglobulin by its molecular characteristics and its lack of expression on malignant B cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Cavalos
/
Anticorpos Monoclonais
/
Antígenos de Superfície
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Vet Immunol Immunopathol
Ano de publicação:
1994
Tipo de documento:
Article