Modulation defect of sodium pump evidenced in diabetic patients by a microcalorimetric study.
Clin Chim Acta
; 228(2): 161-70, 1994 Aug.
Article
em En
| MEDLINE
| ID: mdl-7988032
ABSTRACT
Sodium pump activity of intact erythrocytes in their own plasma was measured by microcalorimetry in 41 healthy subjects and 35 insulin-dependent diabetic patients. Results show that modulation of the sodium pump is altered in diabetic patients. Addition of insulin increases functioning of the Na(+)-K+ pump in controls but has no effect in diabetic patients. These subjects show a slower response of the Na(+)-K+ pump to the inhibitory effect of ouabain. Cross-incubation experiments suggest that these findings may be explained by the existence of a plasmatic factor that impairs the modulation of the sodium pump in diabetic patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Calorimetria
/
ATPase Trocadora de Sódio-Potássio
/
Diabetes Mellitus Tipo 1
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Clin Chim Acta
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
França