A yeast gene necessary for bud-site selection encodes a protein similar to insulin-degrading enzymes.
Nature
; 372(6506): 567-70, 1994 Dec 08.
Article
em En
| MEDLINE
| ID: mdl-7990931
ABSTRACT
Cells of the yeast Saccharomyces cerevisiae choose bud sites in a non-random spatial pattern that depends on mating type axial for haploid cells and bipolar for a/alpha diploid cells. We identified a mutant yeast, axl 1, in which the budding pattern is altered from axial to bipolar. Expression of the AXL1 gene is repressed in a/alpha diploid cells. With the ectopic expression of AXL1, a/alpha cells exhibited an axial budding pattern, thus AXL1 is a key morphological determinant that distinguishes the budding pattern of haploid cells from that of a/alpha diploid cells. AXL1 encodes a protein similar in sequence of the human and Drosophila insulin-degrading enzymes and to the Escherichia coli ptr gene product. The axial budding pattern might result from degradation of a target protein by the putative Axl1 protease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Proteínas Fúngicas
/
Proteínas de Saccharomyces cerevisiae
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nature
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Japão