Determination of local oxygen consumption rates in tumors.
Cancer Res
; 54(13): 3333-6, 1994 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-8012945
ABSTRACT
At any location in a respiring tissue, partial pressure of oxygen (PO2) is influenced by the local oxygen consumption rate. Consumption rates in vascular tumor tissues have previously been estimated for macroscopic regions. Using oxygen electrodes, we measured PO2 profiles across microregions (87 microns to 286 microns wide) of tumors (R3230AC mammary adenocarcinoma) in a rat dorsal skin flap preparation and mapped adjacent microvessels. By comparing measured PO2 values with theoretical simulations, we deduced local consumption rates. Results for six profiles ranged from 0.83 to 2.22 cm3 O2/100 g/min. The mean (+/- SD) was 1.52 +/- 0.51 cm3 O2/100 g/min. This technique permits investigation of variations in consumption at a microregional level.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
/
Modelos Biológicos
/
Neoplasias
Limite:
Animals
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1994
Tipo de documento:
Article