[Effect of Oren-gedoku-to on changes in hexobarbital-induced sleeping time in chlorpromazine-treated mice].
Yakugaku Zasshi
; 114(6): 431-4, 1994 Jun.
Article
em Ja
| MEDLINE
| ID: mdl-8051630
ABSTRACT
The effects of Oren-gedoku-to on the hypnotic duration induced by hexobarbital, and on the change of this duration in chlorpromazine-treated mice were investigated. Single dose of Oren-gedoku-to (1.0 or 2.0 g/kg, p.o.) or chlorpromazine (10 mg/kg, p.o.) prolonged the hexobarbital hypnosis time. And the simultaneous dose of chlorpromazine (6.0 mg/kg, p.o.) and Orengedoku-to (1.0 g/kg, p.o.) indicated the equal effect for the administration of chlorpromazine (10.0 mg/kg, p.o.) alone. Although the mechanism of the action remains to be unknown, administration of Oren-gedoku-to in combination with chlorpromazine seems to be useful from the standpoint of alleviation of the side-effects caused by less dose.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sono
/
Medicamentos de Ervas Chinesas
/
Clorpromazina
/
Hexobarbital
Limite:
Animals
Idioma:
Ja
Revista:
Yakugaku Zasshi
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Japão