Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107.
Nucleic Acids Res
; 22(6): 946-52, 1994 Mar 25.
Article
em En
| MEDLINE
| ID: mdl-8152925
ABSTRACT
Cyclins, TFIIB and RB play major roles in cell cycle and/or gene regulation. Earlier work has suggested common ancestry for the TFIIB repeats and RB pocket B which share 20% sequence identity. We now report that database searches with profiles based on a multiple alignment of cyclin core regions (the 'cyclin box') detect the TFIIB repeats with equivalent scores to divergent cyclins. Several features of the sequences support the notion of common ancestry e.g. cyclins A/B, C and D share approximately 20-30% identity but each have approximately 15-20% identity with vertebrate TFIIB, showing that conserved cyclin features underlie the match. These results suggest the presence of a domain superfamily, which we term the TR domain, in nuclear regulatory proteins belonging to the TFIIB, cyclin and RB families, that has been duplicated many times during eukaryotic evolution. The TR domain appears to function in protein-protein interactions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteína do Retinoblastoma
/
Ciclinas
Idioma:
En
Revista:
Nucleic Acids Res
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Alemanha