Quantitative assessment of the blood-aqueous barrier in human eyes with malignant or benign uveal tumors.
Am J Ophthalmol
; 117(4): 521-8, 1994 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-8154537
ABSTRACT
We assessed alterations of the blood-aqueous barrier in 43 eyes with malignant melanoma (31 choroidal and 12 ciliary body), 40 eyes with benign uveal tumors, and 199-age matched normal control eyes. Aqueous flare was quantified with the laser flare-cell meter and correlated with clinical and histopathologic findings. Aqueous flare (photon counts/ms) was significantly higher in melanoma eyes (20.91 +/- 12.40) than in eyes with benign tumors (4.26 +/- 1.55) (P < .0001) and normal control eyes (3.99 +/- 1.14) (P < .0001). In melanoma eyes, clinical and histologic findings associated with significantly increased aqueous flare values were as follows tumor height, serous retinal detachment, tumor necrosis, lymphocytic tumor infiltration, and tumor hemorrhage. Development and growth of uveal melanomas are accompanied by marked alterations of the blood-aqueous barrier. The noninvasive laser flare-cell meter may give useful additional information about malignant and benign uveal tumors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Humor Aquoso
/
Neoplasias Uveais
/
Sangue
/
Melanoma
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Ophthalmol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Alemanha