Hexahydrobenzo[a]phenanthridines: novel dopamine D3 receptor ligands.
Eur J Pharmacol
; 239(1-3): 271-3, 1993 Aug 03.
Article
em En
| MEDLINE
| ID: mdl-8223910
ABSTRACT
We report that certain substituted hexahydrobenzo[a]phenanthridines are novel high affinity ligands selective for the dopamine D3 receptor. These data demonstrate that substitutions on the heterocyclic nitrogen and the pendant phenyl ring of this nucleus cause a marked increase in both affinity and selectivity for dopamine D3 vs. D2 receptors. Thus, these compounds represent important new tools to study the pharmacology of dopamine D3 receptors, and may also provide an opportunity for the synthesis of new radioligands for dopamine D3 receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenantridinas
/
Receptores Dopaminérgicos
/
Receptores de Dopamina D2
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1993
Tipo de documento:
Article