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Protection of the brain during hypothermic perfusion.
Mohri, H; Sadahiro, M; Akimoto, H; Haneda, K; Tabayashi, K; Ohmi, M.
Afiliação
  • Mohri H; Department of Thoracic and Cardiovascular Surgery, Tohoku University School of Medicine, Sendai, Japan.
Ann Thorac Surg ; 56(6): 1493-6, 1993 Dec.
Article em En | MEDLINE | ID: mdl-8267476
ABSTRACT
The adequacy of the circuits for brain perfusion has been explored by hemodynamic assessment using the ability of the brain to autoregulate blood flow as an indicator, and by morphologic observation using carbon black or Evans blue infusion into the brain perfused antegradely or retrogradely. It is concluded that the safe pressure of cerebral perfusion needed to maintain cerebral integrity is between 40 and 50 mm Hg in both normothermic and hypothermic perfusions, a pressure that can be generated by nonpulsatile pump flows through the pump greater than 40 mL.kg-1 x min-1. Morphologic studies revealed development of focal infarctions in the brain and destruction of the blood-brain barrier by retrograde cerebral perfusion. The retrograde approach, therefore, is definitely inferior to the antegrade method. Antegrade perfusion for 90 minutes, however, produced minimal cerebral edema, suggesting the need for further improvement even in techniques of antegrade perfusion.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infarto Cerebral / Circulação Extracorpórea / Hipotermia Induzida Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Ann Thorac Surg Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Japão
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infarto Cerebral / Circulação Extracorpórea / Hipotermia Induzida Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Ann Thorac Surg Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Japão