Alzheimer's disease histologically proven studied by MRI and MRS: two cases.
Magn Reson Imaging
; 11(8): 1209-15, 1993.
Article
em En
| MEDLINE
| ID: mdl-8271908
ABSTRACT
Two patients affected by severe Alzheimer's disease (AD) were investigated by MRI and image-guided 31P MRS. In one case, 1H MRS was additionally performed. In both cases the diagnosis of AD was confirmed, post mortem, by the pathologist. The spectral parameters of the 31P MR spectra were estimated by fitting the 31P MR signals in the time domain. Our 31P MRS results suggest that it is possible to detect the membrane catabolism, as indexed with the level of PDE resonances visible in in vivo 31P MRS, at least in severe AD cases. The 1H spectrum from AD brain showed a marked decrease of NAA signal respect to choline.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Imageamento por Ressonância Magnética
/
Espectroscopia de Ressonância Magnética
/
Doença de Alzheimer
Limite:
Aged
/
Aged80
/
Female
/
Humans
Idioma:
En
Revista:
Magn Reson Imaging
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Itália