Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolin.
Science
; 263(5149): 969-71, 1994 Feb 18.
Article
em En
| MEDLINE
| ID: mdl-8310295
ABSTRACT
Obstruction of airways by viscous sputum causes lung damage in patients with cystic fibrosis (CF). Sputum samples from CF patients were shown to contain filamentous actin. Human plasma gelsolin, a protein that severs actin filaments, rapidly decreased the viscosity of CF sputum samples in vitro. Gc globulin and deoxyribonuclease I, proteins that sequester monomeric actin but do not sever actin filaments, were less efficient than gelsolin in diminishing sputum viscosity. These results suggest that gelsolin may have therapeutic potential as a mucolytic agent in CF patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escarro
/
Actinas
/
Gelsolina
/
Fibrose Cística
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1994
Tipo de documento:
Article