Alzheimer's disease: a piscatorial trek.
Genet Epidemiol
; 10(6): 395-400, 1993.
Article
em En
| MEDLINE
| ID: mdl-8314033
ABSTRACT
The evidence for linkage between Alzheimer's disease and markers on both chromosomes 19 and 21 [Pericak-Vance et al., 1991] by the affected-pedigree-member (APM) method [Weeks and Lange, 1988] cannot be replicated on any of the available GAW8 data sets when marker allele frequencies are estimated from the combined sample. The strong dependence of the APM method on accurate estimation of marker allele frequencies, and the effects of noninformative pairs and of genetic distance in informative pairs of relatives are illustrated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
Limite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Genet Epidemiol
Assunto da revista:
EPIDEMIOLOGIA
/
GENETICA MEDICA
Ano de publicação:
1993
Tipo de documento:
Article