[Thrombolytic effect of plasmin, miniplasmin and fibrinolysin in simulated intraocular hemorrhage]. / Tromboliticheskoe deistvie plazmina, miniplazmina i fibrinolizina v usloviiakh modelirovaniia vnutriglaznogo krovoizliianiia.
Ukr Biokhim Zh (1978)
; 65(1): 93-7, 1993.
Article
em Ru
| MEDLINE
| ID: mdl-8351749
ABSTRACT
The fibrinolytic properties of the preparations of plasmin (Pm), mixture of plasminogen and streptokinase (Pg+Sk), miniplasmin (m-Pm) and fibrinolysin have been investigated on the models of rabbit's hyphema. The action of preparations of Pm and Pg+Sk had approximately equal therapeutic index--the total destruction of clots proceeded for 12.0 days, that was 6.6 days less than in the control group. The therapeutic effect for m-Pm was 3.6 days. The dose of preparation of m-Pm, necessary for total destruction of clots, was 15-20% greater than for the same dose of Pg+Sk. The preparation of fibrinolysin, used in the same quantities of proteolytic activity, as Pg and m-Pg, (16 caseinolytic units per 1 injection) had no therapeutic effect.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Hifema
/
Fibrinolisina
Limite:
Animals
Idioma:
Ru
Revista:
Ukr Biokhim Zh (1978)
Ano de publicação:
1993
Tipo de documento:
Article