Developmental differences of angiotensinogen mRNA in the preoptic area between spontaneously hypertensive and age-matched Wistar-Kyoto rats.
Brain Res Mol Brain Res
; 19(1-2): 115-20, 1993 Jul.
Article
em En
| MEDLINE
| ID: mdl-8361333
ABSTRACT
In order to know the possible involvement of the central angiotensin system in hypertension, angiotensinogen mRNA (AomRNA) levels of eight discrete brain areas were measured by Northern blot hybridization analysis in the spontaneously hypertensive rats (SHR), compared with those in age-matched normotensive Wistar-Kyoto rats (WKY). In 16-week-old SHR (hypertensive stage), AomRNA levels in the preoptic area (POA), but not in the ventromedial hypothalamus, lateral hypothalamus and mammillary body, among the hypothalamic nuclei, were higher (approximate 50%) than in WKY. There were no differences in other brain areas, such as the striatum, septum, amygdala and cerebellum between both the strains. The AomRNA levels in POA were already higher (38%) in 4-week-old SHR (prehypertensive stage) without significance, and the difference was augmented (82%) in 7-week-old SHR (evolving stage). These results suggest that the developmental changes of AomRNA levels at POA may be related in some aspect to hypertension process.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Área Pré-Óptica
/
Ratos Endogâmicos SHR
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Ratos Endogâmicos WKY
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Encéfalo
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Envelhecimento
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RNA Mensageiro
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Angiotensinogênio
Limite:
Animals
Idioma:
En
Revista:
Brain Res Mol Brain Res
Assunto da revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Japão