[The anti-cicatrization effect of low dosage 5-Fu after trabeculectomy in late glaucoma].

ABSTRACT

54 patients (66 eyes) of late primary glaucoma were divided into 5-Fluorouracil and control groups before trabeculectomy surgery. The 5-Fu group received subconjunctival injections of 5-Fu 3mg postoperatively and on each of the 6 ensuing days. An average follow-up of 14 months revealed that (1) functional filtering blebs in the 5-Fu group and the control group were 100% and 60% respectively; (2) the postoperative mean diurnal peak IOP was 16.3 +/- 4.9 mmHg in the 5-Fu group and 20.1 +/- 5.2 mmHg in the control group (P < 0.01), and eyes with diurnal IOP < 21 mmHg were 90% in the 5-Fu group and 26% in the control group at the end of the second postoperative year; and (3) the postoperative complications between the 2 groups were comparable, except for shortterm corneal defects in 7 eyes (21.2%) of the 5-Fu group.