Influence of human recombinant interleukin-1 beta on the enantioselective disposition of propranolol in rats.
Biochem Pharmacol
; 45(1): 1-6, 1993 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-8424804
ABSTRACT
The influence of i.v. administration of 10 micrograms/kg recombinant human interleukin-1 beta (rhIL-1 beta), a putative mediator of inflammation, on the pharmacokinetics and metabolism of the propranolol enantiomers was studied in rats aged 3, 12 and 24 months. After oral administration of rac-propranolol to control rats of the three age groups, the plasma concentrations of (R)-propranolol were higher than those of (S)-propranolol. Administration of IL-1 beta increased the plasma concentrations of the (R)-enantiomer markedly and significantly, those of the (S)-enantiomer only to a lesser degree. For both enantiomers an important increase in plasma binding was found in the IL-1 beta-treated rats, which was linked to the increase in alpha 1-acid glycoprotein levels. The in vitro clearance, measured in 3-month-old rats using the 9000 g liver fraction, was for neither of the propranolol enantiomers influenced by IL-1 beta treatment, which is in keeping with the unchanged cytochrome P450 content. The enantioselective influence of IL-1 beta treatment on the pharmacokinetics of propranolol was also present in 12- and 24-month-old rats, although somewhat less pronounced in the latter group. Our results show an enantioselective influence of IL-1 beta treatment on the pharmacokinetics of propranolol in the rat, favouring the (R)-enantiomer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propranolol
/
Interleucina-1
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Biochem Pharmacol
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Bélgica