Corynebacterium parvum and cyclophosphamide as combination treatment for a murine mammary adenocarcinoma.
Cancer Res
; 37(4): 1137-40, 1977 Apr.
Article
em En
| MEDLINE
| ID: mdl-844041
ABSTRACT
Weekly i.p. injections of killed Corynebacterium parvum and of cyclophosphamide (given on different days) strongly inhibited growth of a transplantable murine mammary adenocarcinoma. A significant portion (40 to 80%) of animals could be made tumor free by means of combined therapy. No tumor-free survivors were obtained with C. parvum alone, and tumor-free mice were obtained with cyclophosphamide alone only at the expense of a high incidence of deaths due to drug toxicity. No evidence of tumor rejection immunity was detected in the tumor-free survivors from the combined treatment protocols, suggesting that this therapeutic regimen is not associated with tumor rejection immunity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propionibacterium acnes
/
Adenocarcinoma
/
Ciclofosfamida
/
Neoplasias Mamárias Experimentais
Tipo de estudo:
Guideline
Limite:
Animals
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1977
Tipo de documento:
Article