Glomerulosclerosis in mice transgenic for native or mutated bovine growth hormone gene.
Kidney Int Suppl
; 39: S90-4, 1993 Jan.
Article
em En
| MEDLINE
| ID: mdl-8468934
ABSTRACT
Mice transgenic for bovine growth hormone (bGH) develop an increase in body weight and glomerular lesions characterized by a disproportionate increment in glomerular volume and progressive mesangial sclerosis. The relationship between glomerular size and body growth in bGH mice was further investigated by examining mice transgenic for a mutated GH gene (bGH-m11) which failed to enhance body growth. The glomeruli in bGH-m11 mice exhibited an increase in size and glomerulosclerosis comparable to those found in bGH mice. The levels of alpha 1 type IV collagen mRNA, as measured by the competitive polymerase chain reaction in isolated microdissected glomeruli, were markedly elevated in mice transgenic for both bGH and bGH-m11 genes. These data suggest that body growth on one hand, and glomerular hypertrophy and sclerosis on the other hand, are mediated by different portions of GH or different second messenger signaling systems.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio do Crescimento
/
Glomerulosclerose Segmentar e Focal
Limite:
Animals
Idioma:
En
Revista:
Kidney Int Suppl
Ano de publicação:
1993
Tipo de documento:
Article