Dicyanogold (I) is a common human metabolite of different gold drugs.
J Rheumatol
; 20(2): 268-72, 1993 Feb.
Article
em En
| MEDLINE
| ID: mdl-8474063
ABSTRACT
Gold based drugs and their metabolites have been characterized using reversed phase, ion pairing chromatography with an inductively coupled plasma mass spectrometer as an element specific detector. For a patient receiving gold sodium thiomalate the principal gold species in the urine is [Au(CN)2]-, which is also seen in a low molecular weight infiltrate of the blood. The same compound is also identified in the urine and blood of a patient taking auranofin and in patients taking solganol. This represents the first identification of a specific gold metabolite in biological fluids taken from patients undergoing gold therapy and the first evidence that different gold drugs have common metabolites.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Cianatos
/
Ouro
Limite:
Humans
Idioma:
En
Revista:
J Rheumatol
Ano de publicação:
1993
Tipo de documento:
Article