Tissue-specific modulation of rat glucocorticoid receptor binding activity by melatonin.
Experientia
; 49(4): 332-4, 1993 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-8477835
ABSTRACT
The effect of melatonin and 2-Iodo-melatonin on nuclear and cytosolic glucocorticoid receptors in the brain, pituitary, thymus and liver has been examined. The results indicate that both melatonin and 2-Iodo-melatonin administration is associated with marked changes in the density and the affinity of cytosolic and nuclear forms of glucocorticoid receptors. These observations are discussed in the context of a possible involvement of pineal melatonin in the mechanisms regulating the behaviour and metabolism of steroid receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Glucocorticoides
/
Melatonina
Limite:
Animals
Idioma:
En
Revista:
Experientia
Ano de publicação:
1993
Tipo de documento:
Article