Basilar arterial construction caused by intracisternal NG-nitro-L-arginine in anesthetized monkeys.
Cardiovasc Res
; 30(5): 663-7, 1995 Nov.
Article
em En
| MEDLINE
| ID: mdl-8595610
ABSTRACT
OBJECTIVES:
The present study was designed to determine whether tonic nitric oxide (NO)-mediated vasodilator innervation participates in basilar arterial dilatation in the anesthetized Japanese monkey.METHODS:
The basilar arterial diameter was angiographically measured, and NG-nitro-L-arginine (L-NNA), a nitric oxide synthase inhibitor, was intracisternally applied.RESULTS:
The injection of L-NNA produced a sustained constriction of the basilar artery, the effect being reversed by the cisternal injection of L-arginine. The vasoconstriction tended to be accelerated by treatment with phentolamine. Under alpha-adrenoceptor blockade, hexamethonium significantly attenuated the vasoconstrictor response to L-NNA. Intracisternal injections of this inhibitor did not alter the systemic blood pressure and heart rate.CONCLUSIONS:
These findings suggest that construction by the NO synthase inhibitor of the monkey basilar artery is associated with suppression of synthesis of NO in vasodilator nerves receiving tonic impulses from the central nervous system. The basilar arterial tone appears to be regulated by nitroxidergic and adrenergic nerves and by NO derived from the endothelium in anesthetized monkeys.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arginina
/
Vasoconstrição
/
Artéria Basilar
/
Óxido Nítrico Sintase
Limite:
Animals
Idioma:
En
Revista:
Cardiovasc Res
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Japão