Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.
Science
; 272(5265): 1187-90, 1996 May 24.
Article
em En
| MEDLINE
| ID: mdl-8638166
ABSTRACT
It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colo
/
Polipose Adenomatosa do Colo
/
Mucosa Intestinal
/
Mosaicismo
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Science
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Reino Unido