Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2.
Science
; 273(5275): 645-7, 1996 Aug 02.
Article
em En
| MEDLINE
| ID: mdl-8662555
ABSTRACT
Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term potentiation (LTP) at the mossy fiber-CA3 synapses. Long-term depression (LTD) induced by low-frequency stimulation, however, was almost fully abolished. The mutant mice performed normally in water maze learning tasks. Thus, the presynaptic mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this hippocampal LTD does not seem to be required for spatial learning.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Sinapses
/
Receptores de Glutamato Metabotrópico
/
Células Piramidais
/
Hipocampo
/
Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão