NMR study of dideoxynucleotides with anti-human immunodeficiency virus (HIV) activity.
J Biochem Biophys Methods
; 31(3-4): 113-21, 1996 Feb 05.
Article
em En
| MEDLINE
| ID: mdl-8675954
ABSTRACT
The molecular structures of 3'-azido-2',3'-dideoxyribosylthymine 5'-triphosphate (AZTTP), 2',3'-dideoxyribosylinosine 5'-triphosphate (ddlTP), 3'-azido-2',3'-dideoxyribosylthymine 5'-monophosphate (AZTMP) and 2',3'-dideoxyribosyladenine 5'-monophosphate (ddAMP) have been studied by NMR to understand their anti-HIV activity. For ddAMP and ddITP, conformations are almost identical with their nucleoside analogues with sugar ring pucker equilibriating between C3'-endo (approximately 75%) and C2'-endo (approximately 25%). AZTMP and AZTTP on the other hand show significant variations in the conformational behaviour compared with 3'-azido-2',3'-dideoxyribosylthymine (AZT). The sugar rings for these nucleotides have a much larger population of C2'-endo (approximately 75%) conformers, like those observed for natural 2'-deoxynucleosides and nucleotides. The major conformers around C5'-O5', C4'-C5' and the glycosidic bonds are the beta 1, gamma + and anti, respectively.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Nucleotídeos de Timina
/
Zidovudina
/
HIV
/
Inosina Trifosfato
Limite:
Humans
Idioma:
En
Revista:
J Biochem Biophys Methods
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Índia