A case of isodicentric 7p as sole abnormality in a patient with acute myeloid leukemia.
Cancer Genet Cytogenet
; 89(2): 132-5, 1996 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-8697419
ABSTRACT
The detection of isochromosomes in the leukemias and in solid tumors has been well described in the literature, the most common being the i(17q), which is found in the blast crisis of CML and terminal stages of acute myeloid leukemia. Reports of isochromosome 7 have, however, been less well represented, particularly isochromosomes of the short arm of chromosome 7, which represent approximately 1% of all reported isochromosomes in neoplasia. We present here a case report of an elderly female patient with AML-M2 who manifested an idic(7p) in the majority of her bone marrow cells. Fluorescence in situ hybridization (FISH) studies with both centromere-7--and chromosome-7--specific DNA probes verified the diagnosis of idic(7p). To the best of our knowledge, this is the first report of this type of leukemia with an acquired idic(7p) as the sole cytogenetic abnormality.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 7
/
Leucemia Mieloide Aguda
/
Isocromossomos
Limite:
Aged
/
Aged80
/
Female
/
Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Holanda