The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo.
Inflammation
; 20(2): 165-75, 1996 Apr.
Article
em En
| MEDLINE
| ID: mdl-8728019
ABSTRACT
Intratracheal instillation of endotoxin (LPS) causes acute pulmonary inflammation characterized by the accumulation of plasma proteins and leukocytes within the pulmonary airways. The synthetic glucocorticoid dexamethasone 1) inhibits the LPS-initiated vascular leak of plasma proteins into the airspace, 2) inhibits the LPS-initiated emigration of neutrophils and lymphocytes into the airspace in a dose-dependent fashion, and 3) inhibits LPS-initiated mRNA and/or bronchoalveolar lavage protein expression of cytokines (TNF, IL-1 and IL-6) and chemokines (MIP-1 alpha, MIP-2 and MCP-1). In conclusion, dexamethasone inhibits both the vascular and cellular aspects of acute inflammation by downregulation of a broad spectrum of inflammatory cytokines and chemokines.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Desconforto Respiratório
/
Toxinas Bacterianas
/
Dexametasona
/
Quimiotaxia de Leucócito
/
Regulação da Expressão Gênica
/
Lipopolissacarídeos
/
Citocinas
/
Endotoxinas
/
Anti-Inflamatórios
/
Neutrófilos
Limite:
Animals
Idioma:
En
Revista:
Inflammation
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos