Pyramidal neurones in human precentral gyrus contain nitric oxide synthase.
Neuroreport
; 6(18): 2532-6, 1995 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-8741756
ABSTRACT
Pyramidal cells in the mammalian neocortex do not normally contain detectable levels of the enzyme nitric oxide synthase. However one region of the human neocortex contains pyramidal neurones that express neuronal nitric oxide synthase activity. These neurons are mainly located in layer V of the precentral gyrus and frontal cortex and are predominantly Betz cells. The proportion of Betz cells stained in the eight brains examined varied from 5 to 80%. The brains of eight rats that had received a stab wound to the parietal cortex were also examined. Following a survival period of 7 or 14 days, small groups of pyramidal neurones surrounding the lesion contained moderate levels of neuronal nitric oxide synthase. We suggest that human pyramidal neurones may start expressing nitric oxide synthase as a response to damage or age-related stress and that the nitric oxide released may have a neuroprotective role.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Piramidais
/
Óxido Nítrico Sintase
/
Córtex Motor
Limite:
Aged
/
Animals
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Neuroreport
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Reino Unido