[Respiratory failure caused by myopathy in severe sepsis]. / Insufficienza ventilatoria da miopatia in corso di sepsi severa.
Minerva Anestesiol
; 62(3): 89-92, 1996 Mar.
Article
em It
| MEDLINE
| ID: mdl-8767153
ABSTRACT
OBJECTIVE:
To describe a generalized myopathic disorder occurred in the convalescence phase of illness of a critically ill patient.SETTING:
Neurological Intensive Care Unit. PATIENT A 43-year-old man with acute leukoencephalopathy and severe sepsis complicated by sustained and prolonged cardiovascular, respiratory and renal failure. After 15 days of complete respiratory autonomy, the patient presented an acute ventilatory failure associated with generalized muscle weakness. Neither a relapse of sepsis nor neurological worsening were detected. MEASUREMENTS ANDRESULTS:
Electromyogram resulted in normal conduction velocity in both motor and sensitive nervous fibers. Muscular biopsy showed marked fiber size variability with several hypotrophic fibers type II fiber grouping, several areas of degeneration-necrosis with macrophage invasion, dishomogeneous oxidative enzymatic activity, no increase in glycogen or lipid content.CONCLUSIONS:
These results excluded critical illness polyneuropathy and all the other known myopathies. Prolonged period of sepsis with multiple organ failure can result in a direct generalized myopathy. This possibility should be kept in mind while treating long term critically ill survivors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Respiratória
/
Sepse
/
Doenças Musculares
Limite:
Adult
/
Humans
/
Male
Idioma:
It
Revista:
Minerva Anestesiol
Ano de publicação:
1996
Tipo de documento:
Article