Localisation of NADPH diaphorase activity and NOS immunoreactivity in astroglia in normal adult rat brain.
Brain Res
; 714(1-2): 135-44, 1996 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-8861618
ABSTRACT
This study demonstrates the co-localisation of NADPH diaphorase activity and GFAP immunoreactivity in non-neuronal cells in weakly fixed brain sections from normal adult rats. The presence of GFAP immunoreactivity in these cells indicates that they are astroglia. In addition, cells possessing the morphological characteristics of astroglia were weakly immunoreactive for the endothelial isoform of nitric oxide synthase (eNOS)--these cells also co-localised NADPH diaphorase activity. Furthermore, cells immunoreactive for eNOS displayed GFAP immunoreactive processes. This cytochemical evidence strongly suggests that resting astroglia are potential sources of nitric oxide--a powerful modulator of cell activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Astrócitos
/
Óxido Nítrico Sintase
/
NADPH Desidrogenase
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Reino Unido