Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics.
Cell
; 87(2): 227-39, 1996 Oct 18.
Article
em En
| MEDLINE
| ID: mdl-8861907
ABSTRACT
Drosophila Enabled is required for proper formation of axonal structures and is genetically implicated in signaling pathways mediated by Drosophila AbI. We have identified two murine proteins, Mena and Evl, that are highly related to Enabled as well as VASP (Vasodilator-Stimulated Phosphoprotein). A conserved domain targets Mena to localized proteins containing a specific proline-rich motif. The association of Mena with the surface of the intracellular pathogen Listeria monocytogenes and the G-actin binding protein profilin suggests that this molecule may participate in bacterial movement by facilitating actin polymerization. Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Citoesqueleto de Actina
/
Proteínas
/
Proteínas de Transporte
/
Moléculas de Adesão Celular
/
Proteínas Contráteis
/
Proteínas do Citoesqueleto
/
Proteínas de Ligação a DNA
Limite:
Animals
Idioma:
En
Revista:
Cell
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos