Neuroblastoma cell culture assay shows that Carcinoscorpius rotundicauda haemolymph neutralizes tetrodotoxin.
Toxicon
; 34(9): 1054-7, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8896198
ABSTRACT
Veratridine facilitates the influx of Na+ into Neuro-2A cells and this process is exacerbated by the presence of a Na+/K(+)-ATPase inhibitor, ouabain, leading to a reduction in cell viability. However, tetrodotoxin neutralizes the cytotoxic effects of veratridine, hence sustaining the viability of Neuro-2A cells. This neutralizing ability was negated when TTX was first reacted with cell-free haemolymph of Carcinoscorpius rotundicauda, resulting in reduced cell viability. These results therefore indicate a bona fide effect of the cell-free haemolymph against tetrodotoxin as demonstrated by in vitro cell culture technique.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ouabaína
/
Tetrodotoxina
/
Veratridina
/
ATPase Trocadora de Sódio-Potássio
/
Neuroblastoma
Limite:
Animals
Idioma:
En
Revista:
Toxicon
Ano de publicação:
1996
Tipo de documento:
Article