[Autoimmune hypoglycemia syndrome with specific anti-human insulin antibodies]. / Síndrome de hipoglucemia autoinmune con anticuerpos específicos anti-insulina humana.
Medicina (B Aires)
; 56(3): 279-83, 1996.
Article
em Es
| MEDLINE
| ID: mdl-9035485
ABSTRACT
A 33 year old woman with episodes of severe hypoglycemia is presented. The studies showed anti-insulin antibodies and variable C-peptide levels. Circulating insulin measured after acid-ethanol extraction, was of 1,600 uU/ml and shown to be human insulin after characterization by HLPC. Specific anti-human insulin antibodies were of high affinity (Ka1 6.20 x 10(10) M-1; Ka2 2.42 x 10(9) M-1). A small cross-reactive porcine and bovine antibody subpopulation was also detected (IgG, light k type chain). Plasmapheresis was undertaken when symptoms were spontaneously declining and turned antibody title negative. Prolonged follow-up showed no relapse of this syndrome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Hipoglicemia
/
Anticorpos Anti-Insulina
Limite:
Adult
/
Female
/
Humans
Idioma:
Es
Revista:
Medicina (B Aires)
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Argentina