A new role for vascular endothelial growth factor and fibroblast growth factors: increasing endothelial resistance to oxidative stress.
FEBS Lett
; 403(2): 139-42, 1997 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-9042954
ABSTRACT
Intracellular oxidative stress was measured in cultured human umbilical vein or bovine aortic endothelial cells exposed to hydrogen peroxide using an oxidation-sensitive vital dye, 2',7'-dichlorofluorescein, and flow cytometry. Vascular endothelial growth factor (VEGF), acidic fibroblast growth factor (aFGF) or basic fibroblast growth factor (bFGF) caused both a 5-10-fold increase in resistance to hydrogen peroxide induced fluorescence and an increase in intracellular reduced glutathione concentration. Increased resistance to oxidative stress mediated by growth factors is likely to be biologically relevant, and may open new avenues for therapeutic protection against oxidative stress.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
/
Fatores de Crescimento Endotelial
/
Fator 2 de Crescimento de Fibroblastos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Reino Unido