Synthesis of alpha- and beta-biotinylated T-antigen.
Carbohydr Res
; 298(3): 153-61, 1997 Mar 05.
Article
em En
| MEDLINE
| ID: mdl-9090812
ABSTRACT
The T-antigen [beta-D-Gal-(1-->3)-D-Ga1NAc] has been linked to biotin through a C6 spacer arm for the detection of a specific 'T-antigen-lectin' complex at the surface and/or on the migration pathway of melanoma cells. When 4,6-di-O-acetyl-2-azido-2-deoxy-3-O-(2,3,4, 6-tetra-O-acetyl-beta-D-galactopyranosyl)-alpha- or -beta-D-galactopyranosyl halides were treated with N-benzyloxycarbonyl or N-fluorenylmethoxycarbonyl protected aminohexanols (used as the spacer arm), unusual stereoselectivities were observed for the synthesis of the alpha and beta anomers. The synthesis of the alpha anomer could only be achieved, in reasonable yields, with the Schiff base of aminohexanol.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biotina
/
Antígenos Glicosídicos Associados a Tumores
/
Biomarcadores Tumorais
/
Antígenos de Neoplasias
Idioma:
En
Revista:
Carbohydr Res
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
França